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Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor

Academic Article
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  • Research
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Overview

authors

  • Heffron, T. P.
  • Berry, M.
  • Castanedo, G.
  • Chang, C.
  • Chuckowree, I.
  • Dotson, J.
  • Folkes, A.
  • Gunzner, Janet Lorraine
  • Lesnick, J. D.
  • Lewis, C.
  • Mathieu, S.
  • Nonomiya, J.
  • Olivero, A.
  • Pang, J.
  • Peterson, D.
  • Salphati, L.
  • Sampath, D.
  • Sideris, S.
  • Sutherlin, D. P.
  • Tsui, Vickie
  • Wan, N. C.
  • Wang, S.
  • Wong, S.
  • Zhu, B. Y.

publication date

  • April 2010

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Dogs
  • Enzyme Inhibitors
  • Female
  • Intracellular Signaling Peptides and Proteins
  • Mice
  • Phosphatidylinositol 3-Kinases
  • Protein Serine-Threonine Kinases
  • Pyrimidines
  • Rats
  • TOR Serine-Threonine Kinases
  • Thiophenes
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Research

keywords

  • Kinase inhibitors
  • PI3K
  • mTOR
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2010.03.046

PubMed ID

  • 20346656
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Additional Document Info

start page

  • 2408

end page

  • 2411

volume

  • 20

issue

  • 8

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