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A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis

Academic Article
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Overview

authors

  • Yin, Yanhai
  • Vafeados, D.
  • Tao, Yi
  • Yoshida, S.
  • Asami, T.
  • Chory, Joanne

publication date

  • January 2005

journal

  • Cell  Journal

abstract

  • Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1, accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulates gene expression is unknown. In this study, we dissect BES1 subdomains and establish that BES1 is a transcription factor that binds to and activates BR target gene promoters both in vitro and in vivo. BES1 interacts with a basic helix-loop-helix protein, BIM1, to synergistically bind to E box (CANNTG) sequences present in many BR-induced promoters. Loss-of-function and gain-of-function mutants of BIM1 and its close family members display BR response phenotypes. Thus, BES1 defines a new class of plant-specific transcription factors that cooperate with transcription factors such as BIM1 to regulate BR-induced genes.

subject areas

  • Amino Acid Sequence
  • Arabidopsis
  • Arabidopsis Proteins
  • Cell Nucleus
  • Gene Expression Regulation, Plant
  • Helix-Loop-Helix Motifs
  • Molecular Sequence Data
  • Nuclear Proteins
  • Phytosterols
  • Transcription Factors
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2004.11.044

PubMed ID

  • 15680330
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Additional Document Info

start page

  • 249

end page

  • 259

volume

  • 120

issue

  • 2

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