Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Sensitivity of genome-wide-association signals to phenotyping strategy: the PROP-TAS2R38 taste association as a benchmark

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Genick, Ulrich
  • Kutalik, Z.
  • Ledda, M.
  • Destito, M. C. S.
  • Souza, M. M.
  • Cirillo, C. A.
  • Godinot, N.
  • Martin, N.
  • Morya, E.
  • Sameshima, K.
  • Bergmann, S.
  • le Coutre, J.

publication date

  • November 2011

journal

  • PLoS One  Journal

abstract

  • Natural genetic variation can have a pronounced influence on human taste perception, which in turn may influence food preference and dietary choice. Genome-wide association studies represent a powerful tool to understand this influence. To help optimize the design of future genome-wide-association studies on human taste perception we have used the well-known TAS2R38-PROP association as a tool to determine the relative power and efficiency of different phenotyping and data-analysis strategies. The results show that the choice of both data collection and data processing schemes can have a very substantial impact on the power to detect genotypic variation that affects chemosensory perception. Based on these results we provide practical guidelines for the design of future GWAS studies on chemosensory phenotypes. Moreover, in addition to the TAS2R38 gene past studies have implicated a number of other genetic loci to affect taste sensitivity to PROP and the related bitter compound PTC. None of these other locations showed genome-wide significant associations in our study. To facilitate further, target-gene driven, studies on PROP taste perception we provide the genome-wide list of p-values for all SNPs genotyped in the current study.

subject areas

  • Adolescent
  • Adult
  • Age Distribution
  • Benchmarking
  • Body Mass Index
  • Female
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Linear Models
  • Logistic Models
  • Male
  • Middle Aged
  • Observer Variation
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Propylthiouracil
  • Receptors, G-Protein-Coupled
  • Taste
  • Taste Perception
  • Taste Threshold
  • Young Adult
scroll to property group menus

Identity

PubMed Central ID

  • PMC3223210

International Standard Serial Number (ISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0027745

PubMed ID

  • 22132133
scroll to property group menus

Additional Document Info

volume

  • 6

issue

  • 11

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support