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Diving into the water: inducible binding conformations for BRD4, TAF1(2), BRD9, and CECR2 bromodomains

Academic Article
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Overview

authors

  • Crawford, T. D.
  • Tsui, Vickie
  • Flynn, E. M.
  • Wang, S.
  • Taylor, A. M.
  • Cote, A.
  • Audia, J. E.
  • Beresini, M. H.
  • Burdick, D. J.
  • Cummings, R.
  • Dakin, L. A.
  • Duplessis, M.
  • Good, A. C.
  • Hewitt, M. C.
  • Huang, H. R.
  • Jayaram, H.
  • Kiefer, J. R.
  • Jiang, Y.
  • Murray, J.
  • Nasveschuk, C. G.
  • Pardo, E.
  • Poy, F.
  • Romero, F. A.
  • Tang, Y.
  • Wang, J.
  • Xu, Z.
  • Zawadzke, L. E.
  • Zhu, X.
  • Albrecht, B. K.
  • Magnuson, S. R.
  • Bellon, S.
  • Cochran, A. G.

publication date

  • June 2016

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Binding Sites
  • Dose-Response Relationship, Drug
  • Fluorescence Resonance Energy Transfer
  • Fluorometry
  • Histone Acetyltransferases
  • Humans
  • Ligands
  • Models, Molecular
  • Molecular Conformation
  • Nuclear Proteins
  • Pyridones
  • Pyrroles
  • Structure-Activity Relationship
  • TATA-Binding Protein Associated Factors
  • Transcription Factor TFIID
  • Transcription Factors
  • Water
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/acs.jmedchem.6b00264

PubMed ID

  • 27219867
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Additional Document Info

start page

  • 5391

end page

  • 5402

volume

  • 59

issue

  • 11

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