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A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

Academic Article
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Overview

authors

  • Laczko, D.
  • Hogan, M. J.
  • Toulmin, S. A.
  • Hicks, P.
  • Lederer, K.
  • Gaudette, B. T.
  • Castano, D.
  • Amanat, F.
  • Muramatsu, H.
  • Oguin, T. H.
  • Ojha, A.
  • Zhang, L. Z.
  • Mu, Z. K.
  • Parks, R.
  • Manzoni, T. B.
  • Roper, B.
  • Strohmeier, S.
  • Tombacz, I.
  • Arwood, L.
  • Nachbagauer, R.
  • Kariko, K.
  • Greenhouse, J.
  • Pessaint, L.
  • Porto, M.
  • Putman-Taylor, T.
  • Strasbaugh, A.
  • Campbell, T. A.
  • Lin, P. J. C.
  • Tam, Y. K.
  • Sempowski, G. D.
  • Farzan, Michael
  • Choe, H.
  • Saunders, K. O.
  • Haynes, B. F.
  • Andersen, H.
  • Eisenlohr, L. C.
  • Weissman, D.
  • Krammer, F.
  • Bates, P.
  • Allman, D.
  • Locci, M.
  • Pardi, N.

publication date

  • 2020

journal

  • Immunity  Journal

subject areas

  • Animals
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • B-Lymphocytes
  • Betacoronavirus
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • COVID-19
  • COVID-19 Vaccines
  • Coronavirus Infections
  • Disease Models, Animal
  • Furin
  • Humans
  • Immunity, Humoral
  • Immunization
  • Immunogenicity, Vaccine
  • Immunologic Memory
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred BALB C
  • Nanoparticles
  • Pandemics
  • Pneumonia, Viral
  • RNA, Messenger
  • RNA, Viral
  • SARS-CoV-2
  • Spike Glycoprotein, Coronavirus
  • Vaccines, Synthetic
  • Viral Vaccines
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Identity

PubMed Central ID

  • PMC7392193

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2020.07.019

PubMed ID

  • 32783919
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Additional Document Info

start page

  • 724

end page

  • 732

volume

  • 53

issue

  • 4

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