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Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifs

Academic Article
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  • Research
  • Identity
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Overview

authors

  • Trujillo, John I
  • Huang, W.
  • Hughes, Robert Owen
  • Rogier, D. J.
  • Turner, S. R.
  • Devraj, R.
  • Morton, P. A.
  • Xue, C. B.
  • Chao, G. F.
  • Covington, M. B.
  • Newton, R. C.
  • Metcalf, B.

publication date

  • March 2011

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Binding Sites
  • Drug Design
  • Models, Molecular
  • Receptors, CCR2
  • Structure-Activity Relationship
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Research

keywords

  • CCR2 antagonists
  • Central penetrance
  • Diazobicyclo[2.2.1]heptane
  • Dofetilide
  • Fluoropyran
  • Inflammatory diseases
  • MCP-1
  • Neuropathic pain
  • hERG
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2011.01.052

PubMed ID

  • 21316220
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Additional Document Info

start page

  • 1827

end page

  • 1831

volume

  • 21

issue

  • 6

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