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Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure-mutagenicity relationships for arylamine metabolites

Academic Article
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Overview

authors

  • Tichenor, Mark
  • Keith, J. M.
  • Jones, W. M.
  • Pierce, J. M.
  • Merit, J.
  • Hawryluk, N.
  • Seierstad, M.
  • Palmer, J. A.
  • Webb, M.
  • Karbarz, M. J.
  • Wilson, S. J.
  • Wennerholm, M. L.
  • Woestenborghs, F.
  • Beerens, D.
  • Luo, L.
  • Brown, S. M.
  • De Boeck, M.
  • Chaplan, S. R.
  • Breitenbucher, J. G.

publication date

  • December 2012

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Amidohydrolases
  • Amines
  • Animals
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors
  • Humans
  • Mixed Function Oxygenases
  • Molecular Structure
  • Mutagenicity Tests
  • Mutagens
  • Rats
  • Structure-Activity Relationship
  • Urea
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Research

keywords

  • Ames II
  • FAAH
  • Fatty acid amide hydrolase
  • Heteroaryl amine
  • Mutagenic
  • Urea
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2012.10.076

PubMed ID

  • 23141911
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Additional Document Info

start page

  • 7357

end page

  • 7362

volume

  • 22

issue

  • 24

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