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Lysophosphatidylcholine activates adipocyte glucose uptake and lowers blood glucose levels in murine models of diabetes

Academic Article
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Overview

authors

  • Yea, Kyungmoo
  • Kim, J.
  • Yoon, J. H.
  • Kwon, T.
  • Kim, J. H.
  • Lee, B. D.
  • Lee, H. J.
  • Lee, S. J.
  • Kim, J. I.
  • Lee, T. G.
  • Baek, M. C.
  • Park, H. S.
  • Park, K. S.
  • Ohba, M.
  • Suh, P. G.
  • Ryu, S. H.

publication date

  • December 2009

journal

  • Journal of Biological Chemistry  Journal

abstract

  • Glucose homeostasis is maintained by the orchestration of peripheral glucose utilization and hepatic glucose production, mainly by insulin. In this study, we found by utilizing a combined parallel chromatography mass profiling approach that lysophosphatidylcholine (LPC) regulates glucose levels. LPC was found to stimulate glucose uptake in 3T3-L1 adipocytes dose- and time-dependently, and this activity was found to be sensitive to variations in acyl chain lengths and to polar head group types in LPC. Treatment with LPC resulted in a significant increase in the level of GLUT4 at the plasma membranes of 3T3-L1 adipocytes. Moreover, LPC did not affect IRS-1 and AKT2 phosphorylations, and LPC-induced glucose uptake was not influenced by pretreatment with the PI 3-kinase inhibitor LY294002. However, glucose uptake stimulation by LPC was abrogated both by rottlerin (a protein kinase Cdelta inhibitor) and by the adenoviral expression of dominant negative protein kinase Cdelta. In line with its determined cellular functions, LPC was found to lower blood glucose levels in normal mice. Furthermore, LPC improved blood glucose levels in mouse models of type 1 and 2 diabetes. These results suggest that an understanding of the mode of action of LPC may provide a new perspective of glucose homeostasis.

subject areas

  • 3T3-L1 Cells
  • Adipocytes
  • Animals
  • Blood Glucose
  • Diabetes Mellitus, Experimental
  • Enzyme Inhibitors
  • Glucose Transporter Type 4
  • Lysophosphatidylcholines
  • Male
  • Mass Spectrometry
  • Mice
  • Models, Biological
  • Phosphatidylinositol 3-Kinases
  • Phosphorylation
  • Protein Kinase C-delta
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Identity

PubMed Central ID

  • PMC2797153

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.M109.024869

PubMed ID

  • 19815546
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Additional Document Info

start page

  • 33833

end page

  • 33840

volume

  • 284

issue

  • 49

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