Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress
Academic Article
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Overview
publication date
- 2004
journal
- Journal of Biological Chemistry Journal
subject areas
- Anoxia
- Ascorbic Acid
- Blotting, Western
- Carcinogens
- Cell Line
- Chromatography, High Pressure Liquid
- Cobalt
- Cysteine Endopeptidases
- DNA-Binding Proteins
- Dose-Response Relationship, Drug
- Genes, Reporter
- Humans
- Hypoxia-Inducible Factor 1
- Hypoxia-Inducible Factor 1, alpha Subunit
- Iron
- Ketoglutaric Acids
- Models, Biological
- Multienzyme Complexes
- Mutation
- Nickel
- Nuclear Proteins
- Oxygen
- Plasmids
- Procollagen-Proline Dioxygenase
- Proline
- Proteasome Endopeptidase Complex
- Protein Structure, Tertiary
- Time Factors
- Transcription Factors
- Transcription, Genetic
- Tumor Suppressor Proteins
- Ubiquitin-Protein Ligases
- Up-Regulation
- Von Hippel-Lindau Tumor Suppressor Protein