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Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

Academic Article
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  • Identity
  • Additional Document Info
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Overview

authors

  • Salnikow, K.
  • Donald, S. P.
  • Bruick, Richard Keith
  • Zhitkovich, A.
  • Phang, J. M.
  • Kasprzak, K. S.

publication date

  • September 2004

journal

  • Journal of Biological Chemistry  Journal

subject areas

  • Anoxia
  • Ascorbic Acid
  • Blotting, Western
  • Carcinogens
  • Cell Line
  • Chromatography, High Pressure Liquid
  • Cobalt
  • Cysteine Endopeptidases
  • DNA-Binding Proteins
  • Dose-Response Relationship, Drug
  • Genes, Reporter
  • Humans
  • Hypoxia-Inducible Factor 1
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Iron
  • Ketoglutaric Acids
  • Models, Biological
  • Multienzyme Complexes
  • Mutation
  • Nickel
  • Nuclear Proteins
  • Oxygen
  • Plasmids
  • Procollagen-Proline Dioxygenase
  • Proline
  • Proteasome Endopeptidase Complex
  • Protein Structure, Tertiary
  • Time Factors
  • Transcription Factors
  • Transcription, Genetic
  • Tumor Suppressor Proteins
  • Ubiquitin-Protein Ligases
  • Up-Regulation
  • Von Hippel-Lindau Tumor Suppressor Protein
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Identity

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.M403057200

PubMed ID

  • 15271983
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Additional Document Info

start page

  • 40337

end page

  • 40344

volume

  • 279

issue

  • 39

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