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Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody

Academic Article
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Overview

authors

  • Rappazzo, C. G.
  • Tse, L. V.
  • Kaku, C. I.
  • Wrapp, D.
  • Sakharkar, M.
  • Huang, D. L.
  • Deveau, L. M.
  • Yockachonis, T. J.
  • Herbert, A. S.
  • Battles, M. B.
  • O'Brien, C. M.
  • Brown, M. E.
  • Geoghegan, J. C.
  • Belk, J.
  • Peng, L. H.
  • Yang, L. L.
  • Hou, Y. X.
  • Scobey, T. D.
  • Burton, Dennis
  • Nemazee, David
  • Dye, J. M.
  • Voss, James
  • Gunn, B. M.
  • McLellan, J. S.
  • Baric, R. S.
  • Gralinski, L. E.
  • Walker, L. M.

publication date

  • January 25, 2021

journal

  • Science  Journal

subject areas

  • Angiotensin-Converting Enzyme 2
  • Animals
  • Antibodies, Monoclonal
  • Antibodies, Viral
  • Antibody Affinity
  • Betacoronavirus
  • Binding Sites
  • Binding Sites, Antibody
  • Broadly Neutralizing Antibodies
  • COVID-19
  • Cell Surface Display Techniques
  • Directed Molecular Evolution
  • Epitopes
  • Humans
  • Immunization, Passive
  • Immunoglobulin Fc Fragments
  • Mice, Inbred BALB C
  • Protein Domains
  • Protein Engineering
  • Receptors, Coronavirus
  • SARS Virus
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome
  • Spike Glycoprotein, Coronavirus
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Identity

PubMed Central ID

  • PMC7963221

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.abf4830

PubMed ID

  • 33495307
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Additional Document Info

start page

  • 823

end page

  • 829

volume

  • 371

issue

  • 6531

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