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Hidden allostery in human glutathione transferase p1-1 unveiled by unnatural amino acid substitutions and inhibition studies

Academic Article
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Overview

authors

  • Hegazy, U. M.
  • Musdal, Y.
  • Mannervik, Bengt

publication date

  • May 2013

journal

  • Journal of Molecular Biology  Journal

subject areas

  • Allosteric Regulation
  • Allosteric Site
  • Amino Acid Substitution
  • Glutathione S-Transferase pi
  • Humans
  • Models, Molecular
  • Protein Subunits
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Research

keywords

  • allostery
  • cooperativity
  • ethacrynic acid
  • glutathione transferase
  • unnatural amino acid
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Identity

International Standard Serial Number (ISSN)

  • 0022-2836

Digital Object Identifier (DOI)

  • 10.1016/j.jmb.2013.01.038

PubMed ID

  • 23399543
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Additional Document Info

start page

  • 1509

end page

  • 1514

volume

  • 425

issue

  • 9

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