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Lysophosphatidic acid (LPA) signaling in vertebrate reproduction

Academic Article
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Overview

authors

  • Ye, X.
  • Chun, Jerold

publication date

  • January 2010

journal

  • Trends in Endocrinology and Metabolism  Journal

abstract

  • Lysophosphatidic acid (LPA) is a cell membrane phospholipid metabolite that can act as an extracellular signal. Its effects are mediated through at least five G protein-coupled receptors, LPA(1-5), and probably others as well. Studies in multiple species including LPAR-deficient mice and humans have identified or implicated important roles for receptor-mediated LPA signaling in multiple aspects of vertebrate reproduction. These include ovarian function, spermatogenesis, fertilization, early embryo development, embryo implantation, embryo spacing, decidualization, pregnancy maintenance and parturition. LPA signaling can also have pathological consequences, influencing aspects of endometriosis and ovarian cancer. Here we review recent progress in LPA signaling research relevant to female and male reproduction.

subject areas

  • Animals
  • Breast
  • Cell Communication
  • Female
  • Genitalia, Female
  • Genitalia, Male
  • Humans
  • Lysophospholipids
  • Male
  • Pregnancy
  • Receptors, Lysophosphatidic Acid
  • Reproduction
  • Signal Transduction
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Identity

PubMed Central ID

  • PMC2818173

International Standard Serial Number (ISSN)

  • 1043-2760

Digital Object Identifier (DOI)

  • 10.1016/j.tem.2009.08.003

PubMed ID

  • 19836970
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Additional Document Info

start page

  • 17

end page

  • 24

volume

  • 21

issue

  • 1

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