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Discovery of camphor-derived pyrazolones as 11β-hydroxysteroid dehydrogenase type 1 inhibitors

Academic Article
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Overview

authors

  • Gillespie, P.
  • Pietranico-Cole, S.
  • Myers, M.
  • Bilotta, J. A.
  • Conde-Knape, K.
  • Fotouhi, N.
  • Goodnow, R. A.
  • Guertin, K. R.
  • Hamilton, M. M.
  • Haynes, Nancy-Ellen
  • Liu, B.
  • Qi, L.
  • Ren, Y.
  • Scott, N. R.
  • So, S. S.
  • Spence, C.
  • Taub, R.
  • Thakkar, K.
  • Tilley, J. W.
  • Zwingelstein, C.

publication date

  • June 2014

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • 11-beta-Hydroxysteroid Dehydrogenase Type 1
  • Animals
  • Camphor
  • Drug Discovery
  • Enzyme Activation
  • Enzyme Inhibitors
  • Female
  • Hydrocortisone
  • Inhibitory Concentration 50
  • Mice
  • Molecular Structure
  • Pyrazolones
  • Rats
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Research

keywords

  • 11 beta HSD1
  • Hit-to-lead
  • Pharmacodynamic model
  • Type 2 diabetes
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2014.04.049

PubMed ID

  • 24815509
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Additional Document Info

start page

  • 2707

end page

  • 2711

volume

  • 24

issue

  • 12

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