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Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active gamma-secretase modulators

Academic Article
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  • Research
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  • Additional Document Info
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Overview

authors

  • Pettersson, M.
  • Johnson, Doug
  • Subramanyam, C.
  • Bales, K. R.
  • am Ende, C. W.
  • Fish, B. A.
  • Green, M. E.
  • Kauffman, G. W.
  • Lira, Ricardo
  • Mullins, P. B.
  • Navaratnam, T.
  • Sakya, S. M.
  • Stiff, C. M.
  • Tran, T. P.
  • Vetelino, B. C.
  • Xie, L.
  • Zhang, L.
  • Pustilnik, L. R.
  • Wood, K. M.
  • O'Donnell, C. J.

publication date

  • April 2012

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Administration, Oral
  • Amides
  • Amyloid Precursor Protein Secretases
  • Animals
  • Benzofurans
  • Drug Design
  • Enzyme Activation
  • Enzyme Inhibitors
  • Guinea Pigs
  • Inhibitory Concentration 50
  • Molecular Structure
  • Protein Binding
  • Rats
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Research

keywords

  • Alzheimer's disease
  • gamma-Secretase modulators
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2012.02.059

PubMed ID

  • 22429469
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Additional Document Info

start page

  • 2906

end page

  • 2911

volume

  • 22

issue

  • 8

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