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Lysophospholipid activation of G protein-coupled receptors

Academic Article
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Overview

authors

  • Mutoh, T.
  • Chun, Jerold

publication date

  • 2008

journal

  • Sub-Cellular Biochemistry  Journal

abstract

  • One of the major lipid biology discoveries in last decade was the broad range of physiological activities of lysophospholipids that have been attributed to the actions of lysophospholipid receptors. The most well characterized lysophospholipids are lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Documented cellular effects of these lipid mediators include growth-factor-like effects on cells, such as proliferation, survival, migration, adhesion, and differentiation. The mechanisms for these actions are attributed to a growing family of 7-transmembrane, G protein-coupled receptors (GPCRs). Their pathophysiological actions include immune modulation, neuropathic pain modulation, platelet aggregation, wound healing, vasopressor activity, and angiogenesis. Here we provide a brief introduction to receptor-mediated lysophospholipid signaling and physiology, and then discuss potential therapeutic roles in human diseases.

subject areas

  • Animals
  • Asthma
  • Autoimmune Diseases
  • Cardiovascular Diseases
  • Cell Adhesion
  • Cell Movement
  • Cell Proliferation
  • Cell Survival
  • Gap Junctions
  • Humans
  • Immunologic Factors
  • Lysophospholipids
  • Neoplasms
  • Receptors, G-Protein-Coupled
  • Receptors, Lysosphingolipid
  • Signal Transduction
  • Sphingosine
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Identity

International Standard Serial Number (ISSN)

  • 0306-0225 (Print) 0306-0225 (Linking)

Digital Object Identifier (DOI)

  • 10.1007/978-1-4020-8831-5_10

PubMed ID

  • 18751915
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Additional Document Info

start page

  • 269

end page

  • 297

volume

  • 49

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