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Transient cells of the developing mammalian telencephalon are peptide-immunoreactive neurons

Academic Article
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Overview

authors

  • Chun, Jerold
  • Nakamura, M. J.
  • Shatz, C. J.

publication date

  • February 1987

journal

  • Nature  Journal

abstract

  • In the development of the mammalian telencephalon, the genesis of neurons destined for the various layers of the cerebral cortex is preceded by the generation of a population of cells that comes to reside in the subplate and marginal zones (see ref. 2 for nomenclature). In the cat, these cells are present in large numbers during development, when their location is correlated with the arrival and accumulation of ingrowing axonal systems and with synapses. However, as the brain matures, the cells disappear and the white matter and layer 1 of the adult emerge. Their disappearance occurs in concert with the invasion of the cortical plate by the axonal systems and with the elimination of the synapses from the subplate. Here we report that the subplate cells have properties typical of mature neurons. They have the ultrastructural appearance of neurons and receive synaptic contacts. They also have long projections and are immunoreactive for MAP2 (microtubule associated protein 2). Further, subpopulations are immunoreactive for one of several neuropeptides. These observations suggest that during the fetal and early postnatal development of the mammalian telencephalon the subplate cells function as neurons in synaptic circuitry that disappears by adulthood.

subject areas

  • Animals
  • Animals, Newborn
  • Autoradiography
  • Cats
  • Histocytochemistry
  • Immunoenzyme Techniques
  • Microtubule-Associated Proteins
  • Neurons
  • Neuropeptides
  • Telencephalon
  • Thymidine
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/325617a0

PubMed ID

  • 3543691
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Additional Document Info

start page

  • 617

end page

  • 620

volume

  • 325

issue

  • 6105

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