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Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3 beta

Academic Article
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Overview

authors

  • Cociorva, O. M.
  • Li, B.
  • Nomanbhoy, T.
  • Li, Q.
  • Nakamura, A.
  • Nakamura, K.
  • Nomura, M.
  • Okada, K.
  • Seto, S.
  • Yumoto, K.
  • Liyanage, M.
  • Zhang, M. C.
  • Aban, A.
  • Leen, B.
  • Szardenings, A. K.
  • Rosenblum, Jonathan
  • Kozarich, J. W.
  • Kohno, Y.
  • Shreder, K. R.

publication date

  • October 2011

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • 4-Quinolones
  • Anti-Bacterial Agents
  • Clinical Trials as Topic
  • Drug Design
  • Drug Evaluation, Preclinical
  • Glycogen Synthase Kinase 3
  • Glycogen Synthase Kinase 3 beta
  • HL-60 Cells
  • High-Throughput Screening Assays
  • Humans
  • Inhibitory Concentration 50
  • Isoenzymes
  • Molecular Targeted Therapy
  • Protein Kinase Inhibitors
  • Structure-Activity Relationship
  • Substrate Specificity
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Research

keywords

  • 3-Carboxylic acid
  • 4-Quinolone
  • Anti-bacterial
  • GSK-3 beta inhibitor
  • Kinase profiling
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2011.07.073

PubMed ID

  • 21873061
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Additional Document Info

start page

  • 5948

end page

  • 5951

volume

  • 21

issue

  • 19

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