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Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold

Academic Article
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Overview

related to degree

  • Ogasawara, Daisuke, Ph.D. in Chemical Biology, Scripps Research 2013 - 2019

authors

  • Rong, J.
  • Mori, W.
  • Xia, X. T.
  • Schafroth, M. A.
  • Zhao, C. Y.
  • Van, R. S.
  • Yamasaki, T.
  • Chen, J. H.
  • Xiao, Z. W.
  • Haider, A.
  • Ogasawara, Daisuke
  • Hiraishi, A.
  • Shao, T.
  • Zhang, Y. D.
  • Chen, Z.
  • Pang, F. W.
  • Hu, K.
  • Xie, L.
  • Fujinaga, M.
  • Kumata, K.
  • Gou, Y. C.
  • Fang, Y.
  • Gu, S. Y.
  • Wei, H. Y.
  • Bao, L.
  • Xu, H.
  • Collier, T. L.
  • Shao, Y. H.
  • Carson, R. E.
  • Cravatt, Benjamin
  • Wang, L.
  • Zhang, M. R.
  • Liang, S. H.

publication date

  • 2021

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Animals
  • Azetidines
  • Binding Sites
  • Dose-Response Relationship, Drug
  • Haplorhini
  • Ligands
  • Models, Molecular
  • Molecular Structure
  • Monoacylglycerol Lipases
  • Positron-Emission Tomography
  • Radiopharmaceuticals
  • Rats
  • Structure-Activity Relationship
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/acs.jmedchem.1c00747

PubMed ID

  • 34569803
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Additional Document Info

start page

  • 14283

end page

  • 14298

volume

  • 64

issue

  • 19

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