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Synthesis and activity of new aryl- and heteroaryl- substituted pyrazole inhibitors of the transforming growth factor-βtype I receptor kinase domain

Academic Article
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Overview

authors

  • Sawyer, J. S.
  • Anderson, B. D.
  • Beight, D. W.
  • Campbell, R. M.
  • Jones, M. L.
  • Herron, D. K.
  • Lampe, J. W.
  • McCowan, J. R.
  • McMillen, W. T.
  • Mort, N.
  • Parsons, S.
  • Smith, E. C. R.
  • Vieth, Michal
  • Wier, L. C.
  • Yan, L.
  • Zhang, F.
  • Yingling, J. M.

publication date

  • September 2003

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • 3T3 Cells
  • Adenosine Triphosphate
  • Animals
  • Benzene Derivatives
  • Binding Sites
  • Cell Line
  • Crystallography, X-Ray
  • Enzyme Inhibitors
  • Humans
  • Inhibitory Concentration 50
  • Mice
  • Mink
  • Mitogen-Activated Protein Kinases
  • Models, Molecular
  • Protein Serine-Threonine Kinases
  • Protein Structure, Tertiary
  • Pyrazoles
  • Receptors, Transforming Growth Factor beta
  • Spodoptera
  • Structure-Activity Relationship
  • p38 Mitogen-Activated Protein Kinases
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm0205705

PubMed ID

  • 12954047
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Additional Document Info

start page

  • 3953

end page

  • 3956

volume

  • 46

issue

  • 19

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