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Identification of a novel conformationally constrained glucagon receptor antagonist

Academic Article
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Overview

authors

  • Lee, E. C. Y.
  • Tu, M.
  • Stevens, B. D.
  • Bian, J.
  • Aspnes, G.
  • Perreault, C.
  • Sammons, M. F.
  • Wright, S. W.
  • Litchfield, J.
  • Kalgutkar, A. S.
  • Sharma, R.
  • Didiuk, M. T.
  • Ebner, D. C.
  • Filipski, K. J.
  • Brown, J.
  • Atkinson, K.
  • Pfefferkorn, Jeff
  • Guzman-Perez, A.

publication date

  • 2014

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Administration, Intravenous
  • Administration, Oral
  • Animals
  • Benzamides
  • Cells, Cultured
  • Dogs
  • Ligands
  • Molecular Conformation
  • Molecular Structure
  • Oxidation-Reduction
  • Protein Binding
  • Pyrimidines
  • Rats
  • Rats, Wistar
  • Receptors, Glucagon
  • Stereoisomerism
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Research

keywords

  • Diabetes mellitus
  • Glucagon receptor antagonist
  • Metabolite
  • Physicochemical properties
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2013.12.090

PubMed ID

  • 24418771
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Additional Document Info

start page

  • 839

end page

  • 844

volume

  • 24

issue

  • 3

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