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Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists

Academic Article
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  • Identity
  • Additional Document Info
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Overview

authors

  • Vilums, M.
  • Zweemer, A. J. M.
  • Yu, Z.
  • de Vries, H.
  • Hillger, J. M.
  • Wapenaar, H.
  • Bollen, I. A. E.
  • Barmare, F.
  • Gross, R.
  • Clemens, J.
  • Krenitsky, Paul
  • Brussee, J.
  • Stamos, D.
  • Saunders, J.
  • Heitman, L. H.
  • Ijzerman, A. P.

publication date

  • October 2013

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Binding, Competitive
  • Cell Line, Tumor
  • Cyclopentanes
  • Humans
  • Indans
  • Indenes
  • Kinetics
  • Ligands
  • Receptors, CCR2
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tetrahydronaphthalenes
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/jm4011737

PubMed ID

  • 24028535
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Additional Document Info

start page

  • 7706

end page

  • 7714

volume

  • 56

issue

  • 19

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