Affinity-based ranking of ligands for DPP-4 from mixtures

Academic Article

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Overview

authors

• Adam, Gregory
• Meng, J.
• Athanasopoulos, J.
• Zhang, X.
• Chapman, K. T.

publication date

• May 2007

journal

• Bioorganic & Medicinal Chemistry Letters  Journal

abstract

• Affinity-based selection strategies have recently emerged as a complement to traditional high throughput screening for the rapid discovery of lead compounds for the large number of protein targets emerging from--omics technologies. Herein, we describe a method for the ranking of mixtures of ligands by affinity selection and apply it to rank order a set of inhibitors for the enzyme dipeptidyl peptidase IV.

subject areas

• Chemistry, Pharmaceutical
• Diabetes Mellitus
• Dipeptidyl Peptidase 4
• Dose-Response Relationship, Drug
• Drug Design
• Enzyme Inhibitors
• Humans
• Inhibitory Concentration 50
• Ligands
• Models, Chemical

Research

keywords

• affinity-based
• dipeptidyl peptidase IV
• mass spectrometry
• mixtures
• rank ordering

Identity

International Standard Serial Number (ISSN)

• 0960-894X

Digital Object Identifier (DOI)

• 10.1016/j.bmcl.2007.02.040

PubMed ID

• 17337342

Additional Document Info

start page

• 2404

end page

• 2407

volume

• 17

issue

• 9