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Affinity-based ranking of ligands for DPP-4 from mixtures

Academic Article
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Overview

authors

  • Adam, Gregory
  • Meng, J.
  • Athanasopoulos, J.
  • Zhang, X.
  • Chapman, K. T.

publication date

  • May 2007

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • Affinity-based selection strategies have recently emerged as a complement to traditional high throughput screening for the rapid discovery of lead compounds for the large number of protein targets emerging from--omics technologies. Herein, we describe a method for the ranking of mixtures of ligands by affinity selection and apply it to rank order a set of inhibitors for the enzyme dipeptidyl peptidase IV.

subject areas

  • Chemistry, Pharmaceutical
  • Diabetes Mellitus
  • Dipeptidyl Peptidase 4
  • Dose-Response Relationship, Drug
  • Drug Design
  • Enzyme Inhibitors
  • Humans
  • Inhibitory Concentration 50
  • Ligands
  • Models, Chemical
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Research

keywords

  • affinity-based
  • dipeptidyl peptidase IV
  • mass spectrometry
  • mixtures
  • rank ordering
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2007.02.040

PubMed ID

  • 17337342
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Additional Document Info

start page

  • 2404

end page

  • 2407

volume

  • 17

issue

  • 9

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