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Discovery of 5-azaindazole (GNE-955) as a potent pan-pim inhibitor with optimized bioavailability

Academic Article
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Overview

authors

  • Wang, X.
  • Kolesnikov, A.
  • Tay, S.
  • Chan, G.
  • Chao, Q.
  • Do, S.
  • Drummond, J.
  • Ebens, A. J.
  • Liu, N.
  • Ly, J.
  • Harstad, E.
  • Hu, H.
  • Moffat, J.
  • Munugalavadla, V.
  • Murray, J.
  • Slaga, D.
  • Tsui, Vickie
  • Volgraf, M.
  • Waliweber, H.
  • Chang, J. H.

publication date

  • May 2017

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Animals
  • Biological Availability
  • Crystallography, X-Ray
  • Humans
  • Indazoles
  • Intestines
  • Molecular Docking Simulation
  • Protein Isoforms
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins c-pim-1
  • Rats
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/acs.jmedchem.7b00418

PubMed ID

  • 28445037
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Additional Document Info

start page

  • 4458

end page

  • 4473

volume

  • 60

issue

  • 10

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