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Variability in response to aspirin: do we understand the clinical relevance?

Academic Article
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Overview

authors

  • Campbell, C. L.
  • Steinhubl, Steven

publication date

  • 2005

journal

  • Journal of Thrombosis and Haemostasis  Journal

abstract

  • Aspirin, an irreversible inhibitor of platelet prostaglandin synthase activity, is the cornerstone of therapy for acute coronary syndromes. In recent years, laboratory and clinical data have accumulated that suggest there may be significant individual variability in the response to aspirin and that the effects of aspirin therapy vary significantly over time. There is, as of yet, no cohesive explanation for this variability. The term 'aspirin resistance' has been loosely applied to situations in which the clinical or ex vivo effects of aspirin are less than expected. In this review we discuss the clinical data regarding this phenomenon and the need for prospective evaluation of aspirin non-responders.

subject areas

  • Acute Disease
  • Angina, Unstable
  • Anti-Inflammatory Agents, Non-Steroidal
  • Aspirin
  • Clinical Trials as Topic
  • Coronary Disease
  • Drug Resistance
  • Humans
  • Myocardial Infarction
  • Platelet Aggregation Inhibitors
  • Time Factors
  • Treatment Outcome
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Identity

International Standard Serial Number (ISSN)

  • 1538-7933

Digital Object Identifier (DOI)

  • 10.1111/j.1538-7836.2005.01119.x

PubMed ID

  • 15703034
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Additional Document Info

start page

  • 665

end page

  • 669

volume

  • 3

issue

  • 4

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