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High affinity binding of conformationally constrained synthetic oligomers to an antigen-specific antibody: Discovery of a diagnostically useful synthetic ligand for murine Type 1 diabetes autoantibodies

Academic Article
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Overview

related to degree

  • Gao, Yu (Tom), Ph.D. in Chemistry, Scripps Research , Transferred from UT Southwestern Medical Center at Dallas 2009 - 2014

authors

  • Doran, T. M.
  • Gao, Yu (Tom)
  • Simanski, S.
  • McEnaney, P.
  • Kodadek, Thomas

publication date

  • November 2015

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Animals
  • Autoantibodies
  • Binding Sites, Antibody
  • Diabetes Mellitus, Type 1
  • Drug Discovery
  • Ligands
  • Mice
  • Molecular Conformation
  • Molecular Structure
  • Peptoids
  • Structure-Activity Relationship
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Research

keywords

  • Antigen surrogate
  • NOD mouse
  • OBOC library screening
  • Peptide tertiary amide
  • Type 1 diabetes
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Identity

PubMed Central ID

  • PMC4607566

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2015.05.046

PubMed ID

  • 26067174
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Additional Document Info

start page

  • 4910

end page

  • 4917

volume

  • 25

issue

  • 21

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