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Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1

Academic Article
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Overview

authors

  • Satoh, T.
  • Kosaka, K.
  • Itoh, K.
  • Kobayashi, A.
  • Yamamoto, M.
  • Shimojo, Y.
  • Kitajima, C.
  • Cui, J.
  • Kamins, J.
  • Okamoto, S. I.
  • Izumi, M.
  • Shirasawa, T.
  • Lipton, Stuart

publication date

  • 2008

journal

  • Journal of Neurochemistry  Journal

subject areas

  • Alkylation
  • Animals
  • COS Cells
  • Catechols
  • Cattle
  • Cells, Cultured
  • Cercopithecus aethiops
  • Cysteine
  • Diterpenes, Abietane
  • Dose-Response Relationship, Drug
  • Intracellular Signaling Peptides and Proteins
  • Kelch-Like ECH-Associated Protein 1
  • Male
  • Mice
  • Mice, Inbred C57BL
  • NF-E2-Related Factor 2
  • Neurons
  • Neuroprotective Agents
  • PC12 Cells
  • Plant Extracts
  • Proteins
  • Rats
  • Rats, Sprague-Dawley
  • Rosmarinus
  • Signal Transduction
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Identity

PubMed Central ID

  • PMC4566957

International Standard Serial Number (ISSN)

  • 0022-3042

Digital Object Identifier (DOI)

  • 10.1111/j.1471-4159.2007.05039.x

PubMed ID

  • 17995931
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Additional Document Info

start page

  • 1116

end page

  • 1131

volume

  • 104

issue

  • 4

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