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Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors

Academic Article
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  • Research
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Overview

authors

  • Neubert, T.
  • Numa, M.
  • Ernst, J.
  • Clemens, J.
  • Krenitsky, Paul
  • Liu, M.
  • Fleck, B.
  • Woody, L.
  • Zuccola, H.
  • Stamos, D.

publication date

  • March 2015

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Adenosine Triphosphate
  • Amides
  • Animals
  • Azepines
  • Benzamides
  • Benzodiazepines
  • Binding Sites
  • Cell Membrane Permeability
  • Crystallography, X-Ray
  • Dogs
  • Drug Evaluation, Preclinical
  • HSP90 Heat-Shock Proteins
  • Indoles
  • Madin Darby Canine Kidney Cells
  • Molecular Docking Simulation
  • Oxazepines
  • Protein Binding
  • Protein Structure, Tertiary
  • Structure-Activity Relationship
  • ortho-Aminobenzoates
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Research

keywords

  • Diazepine
  • HSP90 inhibitor
  • Macrocycle
  • Oaxazepine
  • Structure based design
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2015.01.023

PubMed ID

  • 25677667
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Additional Document Info

start page

  • 1338

end page

  • 1342

volume

  • 25

issue

  • 6

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