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Artificial protein cavities as specific ligand-binding templates: characterization of an engineered heterocyclic cation-binding site that preserves the evolved specificity of the parent protein

Academic Article
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Overview

related to degree

  • Gunn, Robin Rosenfeld, Ph.D. in Biology, Scripps Research 1995 - 2002

authors

  • Musah, R. A.
  • Jensen, G. M.
  • Bunte, S. W.
  • Gunn, Robin Rosenfeld
  • Goodin, D. B.

publication date

  • January 2002

journal

  • Journal of Molecular Biology  Journal

subject areas

  • Amino Acid Substitution
  • Binding Sites
  • Cations
  • Crystallization
  • Crystallography, X-Ray
  • Cytochrome-c Peroxidase
  • Entropy
  • Hydrogen Bonding
  • Ligands
  • Models, Molecular
  • Mutation
  • Protein Binding
  • Protein Engineering
  • Protons
  • Static Electricity
  • Substrate Specificity
  • Thermodynamics
  • Tryptophan
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Research

keywords

  • cavity complementation
  • cavity mutant
  • chemical rescue
  • protein engineering
  • protein-ligand binding
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Identity

International Standard Serial Number (ISSN)

  • 0022-2836

Digital Object Identifier (DOI)

  • 10.1006/jmbi.2001.5287

PubMed ID

  • 11812152
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Additional Document Info

start page

  • 845

end page

  • 857

volume

  • 315

issue

  • 4

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