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Discovery of 5-aryl-1,3-dihydro-2H-imidazo 4,5-b pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis

Academic Article
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Overview

authors

  • Layton, M. E.
  • Reif, A. J.
  • Hartingh, T. J.
  • Rodzinak, K.
  • Dudkin, V.
  • Wang, C.
  • Arrington, K.
  • Kelly, M. J.
  • Garbaccio, Robert
  • O'Brien, J. A.
  • Magliaro, B. C.
  • Uslaner, J. M.
  • Huszar, S. L.
  • Fillgrove, K. L.
  • Tang, C.
  • Kuo, Y.
  • Jacobson, M. A.

publication date

  • February 2016

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Allosteric Regulation
  • Animals
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Imidazoles
  • Locomotion
  • Protein Binding
  • Psychotic Disorders
  • Pyridines
  • Pyridones
  • Rats
  • Receptors, Metabotropic Glutamate
  • Structure-Activity Relationship
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Research

keywords

  • Metabotropic glutamate receptor
  • Positive allosteric modulator
  • Schizophrenia
  • mGlu2 PAM
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2016.01.021

PubMed ID

  • 26810316
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Additional Document Info

start page

  • 1260

end page

  • 1264

volume

  • 26

issue

  • 4

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