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Investigations of enantiopure nicotine haptens using an adjuvanting carrier in anti-nicotine vaccine development

Academic Article
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Overview

related to degree

  • Jacob, Nicholas Taylor, Ph.D. in Chemical Biology, Scripps Research 2013 - 2018

authors

  • Jacob, Nicholas Taylor
  • Lockner, Jonathan
  • Schlosburg, J. E.
  • Ellis, B. A.
  • Eubanks, L. M.
  • Janda, Kim

publication date

  • March 2016

journal

  • Journal of Medicinal Chemistry  Journal

abstract

  • Despite efforts to produce suitable smoking cessation aids, addiction to nicotine continues to carry a substantive risk of recidivism. An attractive alternative to current therapies is the pharmacokinetic strategy of antinicotine vaccination. A major hurdle in the development of the strategy has been to elicit a sufficiently high antibody concentration to curb nicotine distribution to the brain. Herein, we detail investigations into a new hapten design, which was able to elicit an antibody response of significantly higher specificity for nicotine. We also explore the use of a mutant flagellin carrier protein with adjuvanting properties. These studies underlie the feasibility of improvement in antinicotine vaccine formulations to move toward clinical efficacy.

subject areas

  • Animals
  • Antibody Formation
  • Drug Carriers
  • Flagellin
  • Haptens
  • Hypothermia
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Nicotine
  • Pain Measurement
  • Serum Albumin, Bovine
  • Smoking Cessation
  • Structure-Activity Relationship
  • Vaccines
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/acs.jmedchem.5b01676

PubMed ID

  • 26918428
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Additional Document Info

start page

  • 2523

end page

  • 2529

volume

  • 59

issue

  • 6

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