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Curation of the mammalian palmitoylome indicates a pivotal role for palmitoylation in diseases and disorders of the nervous system and cancers

Academic Article
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Overview

authors

  • Sanders, S. S.
  • Martin, D. D. O.
  • Butland, S. L.
  • Lavallee-Adam, M.
  • Calzolari, D.
  • Kay, C.
  • Yates III, John
  • Hayden, M. R.

publication date

  • August 2015

journal

  • PLoS Computational Biology  Journal

abstract

  • Palmitoylation involves the reversible posttranslational addition of palmitate to cysteines and promotes membrane binding and subcellular localization. Recent advancements in the detection and identification of palmitoylated proteins have led to multiple palmitoylation proteomics studies but these datasets are contained within large supplemental tables, making downstream analysis and data mining time-consuming and difficult. Consequently, we curated the data from 15 palmitoylation proteomics studies into one compendium containing 1,838 genes encoding palmitoylated proteins; representing approximately 10% of the genome. Enrichment analysis revealed highly significant enrichments for Gene Ontology biological processes, pathway maps, and process networks related to the nervous system. Strikingly, 41% of synaptic genes encode a palmitoylated protein in the compendium. The top disease associations included cancers and diseases and disorders of the nervous system, with Schizophrenia, HD, and pancreatic ductal carcinoma among the top five, suggesting that aberrant palmitoylation may play a pivotal role in the balance of cell death and survival. This compendium provides a much-needed resource for cell biologists and the palmitoylation field, providing new perspectives for cancer and neurodegeneration.

subject areas

  • Cysteine
  • Databases, Protein
  • Humans
  • Lipoylation
  • Neoplasms
  • Nervous System Diseases
  • Palmitates
  • Proteome
  • Proteomics
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Identity

PubMed Central ID

  • PMC4537140

International Standard Serial Number (ISSN)

  • 1553-734X

Digital Object Identifier (DOI)

  • 10.1371/journal.pcbi.1004405

PubMed ID

  • 26275289
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Additional Document Info

start page

  • e1004405

volume

  • 11

issue

  • 8

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