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Cryptochromes: bringing the blues to circadian rhythms

Academic Article
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Overview

authors

  • Devlin, P. F.
  • Kay, Steve A.

publication date

  • August 1999

journal

  • Trends in Cell Biology  Journal

abstract

  • Cryptochromes are blue/UV-A-absorbing photoreceptor proteins discovered originally in plants and so named because their nature proved elusive in over a century of research. Now we know that the photoreceptor essential for proper seedling establishment in blue light has homologues in the animal kingdom - in insects, in mice and in humans. In recent months, evidence has emerged pointing to a common role for cryptochromes in all of these organisms in entraining the circadian clock, a biochemical timing mechanism running within cells, synchronizing metabolism to the daily light-dark cycle and having consequences on a much larger scale in the regulation of behaviour such as the sleep-wake cycle.

subject areas

  • Animals
  • Arabidopsis
  • Arabidopsis Proteins
  • Biological Clocks
  • Circadian Rhythm
  • Cryptochromes
  • Drosophila
  • Drosophila Proteins
  • Eye Proteins
  • Flavoproteins
  • Humans
  • Mice
  • Photoreceptor Cells
  • Photoreceptor Cells, Invertebrate
  • Receptors, G-Protein-Coupled
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Identity

International Standard Serial Number (ISSN)

  • 0962-8924

Digital Object Identifier (DOI)

  • 10.1016/s0962-8924(99)01611-6

PubMed ID

  • 10407408
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Additional Document Info

start page

  • 295

end page

  • 298

volume

  • 9

issue

  • 8

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