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Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase

Academic Article
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  • Research
  • Identity
  • Additional Document Info
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Overview

authors

  • Staben, S. T.
  • Blaquiere, N.
  • Tsui, Vickie
  • Kolesnikov, A.
  • Do, S.
  • Bradley, E. K.
  • Dotson, J.
  • Goldsmith, R.
  • Heffron, T. P.
  • Lesnick, J.
  • Lewis, C.
  • Murray, J.
  • Nonomiya, J.
  • Olivero, A. G.
  • Pang, J.
  • Rouge, L.
  • Salphati, L.
  • Wei, B.
  • Wiesmann, C.
  • Wu, P.

publication date

  • February 2013

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Amides
  • Benzothiazoles
  • Benzoxepins
  • Binding Sites
  • Crystallography, X-Ray
  • Enzyme Activation
  • Enzyme Inhibitors
  • Humans
  • Models, Molecular
  • Phosphatidylinositol 3-Kinases
  • Thiophenes
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Research

keywords

  • Isostere
  • PI3-kinase
  • Property-guided design
  • Structure-based design
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2012.10.121

PubMed ID

  • 23265894
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Additional Document Info

start page

  • 897

end page

  • 901

volume

  • 23

issue

  • 3

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