Cis-Amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase

Academic Article

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• Research
• Identity
• Additional Document Info
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Overview

authors

• Staben, S. T.
• Blaquiere, N.
• Tsui, Vickie
• Kolesnikov, A.
• Do, S.
• Bradley, E. K.
• Dotson, J.
• Goldsmith, R.
• Heffron, T. P.
• Lesnick, J.
• Lewis, C.
• Murray, J.
• Nonomiya, J.
• Olivero, A. G.
• Pang, J.
• Rouge, L.
• Salphati, L.
• Wei, B.
• Wiesmann, C.
• Wu, P.

publication date

• February 2013

journal

• Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

• Amides
• Benzothiazoles
• Benzoxepins
• Binding Sites
• Crystallography, X-Ray
• Enzyme Activation
• Enzyme Inhibitors
• Humans
• Models, Molecular
• Phosphatidylinositol 3-Kinases
• Thiophenes

Research

keywords

• Isostere
• PI3-kinase
• Property-guided design
• Structure-based design

Identity

International Standard Serial Number (ISSN)

• 0960-894X

Digital Object Identifier (DOI)

• 10.1016/j.bmcl.2012.10.121

PubMed ID

• 23265894

Additional Document Info

start page

• 897

end page

• 901

volume

• 23

issue

• 3