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Discovery of pyrrolidine-containing GPR40 agonists: stereochemistry effects a change in binding mode

Academic Article
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  • Overview
  • Identity
  • Additional Document Info
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Overview

authors

  • Jurica, E. A.
  • Wu, X.
  • Williams, K. N.
  • Hernandez, A. S.
  • Nirschl, David
  • Rampulla, R. A.
  • Mathur, A.
  • Zhou, M.
  • Cao, G.
  • Xie, C.
  • Jacob, B.
  • Cai, H.
  • Wang, T.
  • Murphy, B. J.
  • Liu, H.
  • Xu, C.
  • Kunselman, L. K.
  • Hicks, M. B.
  • Sun, Q.
  • Schnur, D. M.
  • Sitkoff, D. F.
  • Dierks, E. A.
  • Apedo, A.
  • Moore, D. B.
  • Foster, K. A.
  • Cvijic, M. E.
  • Panemangalore, R.
  • Flynn, N. A.
  • Maxwell, B. D.
  • Hong, Y.
  • Tian, Y.
  • Wilkes, J. J.
  • Zinker, B. A.
  • Whaley, J. M.
  • Barrish, J. C.
  • Robl, J. A.
  • Ewing, W. R.
  • Ellsworth, B. A.

publication date

  • February 2017

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Animals
  • Blood Glucose
  • Cell Line
  • Cells, Cultured
  • Diabetes Mellitus, Type 2
  • Glucagon-Like Peptide 1
  • Humans
  • Hypoglycemic Agents
  • Insulin
  • Male
  • Mice, Inbred C57BL
  • Models, Molecular
  • Pyrrolidines
  • Rats
  • Receptors, G-Protein-Coupled
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/acs.jmedchem.6b01559

PubMed ID

  • 28112924
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Additional Document Info

start page

  • 1417

end page

  • 1431

volume

  • 60

issue

  • 4

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