Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Targeting protein aggregation for the treatment of degenerative diseases

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

related to degree

  • Monteiro, Cecilia, Ph.D. in Chemical Biology, Scripps Research 2014 - 2018

authors

  • Eisele, Y. S.
  • Monteiro, Cecilia
  • Fearns, C.
  • Encalada, Sandra
  • Wiseman, R. Luke
  • Powers, Evan
  • Kelly, Jeffery

publication date

  • November 2015

journal

  • Nature Reviews Drug Discovery  Journal

abstract

  • The aggregation of specific proteins is hypothesized to underlie several degenerative diseases, which are collectively known as amyloid disorders. However, the mechanistic connection between the process of protein aggregation and tissue degeneration is not yet fully understood. Here, we review current and emerging strategies to ameliorate aggregation-associated degenerative disorders, with a focus on disease-modifying strategies that prevent the formation of and/or eliminate protein aggregates. Persuasive pharmacological and genetic evidence now supports protein aggregation as the cause of postmitotic tissue dysfunction or loss. However, a more detailed understanding of the factors that trigger and sustain aggregate formation and of the structure-activity relationships underlying proteotoxicity is needed to develop future disease-modifying therapies.

subject areas

  • Animals
  • Biological Factors
  • Humans
  • Neurodegenerative Diseases
  • Prealbumin
  • Protein Aggregation, Pathological
  • Protein Folding
  • Protein Transport
  • Structure-Activity Relationship
  • Treatment Outcome
scroll to property group menus

Identity

PubMed Central ID

  • PMC4628595

International Standard Serial Number (ISSN)

  • 1474-1776

Digital Object Identifier (DOI)

  • 10.1038/nrd4593

PubMed ID

  • 26338154
scroll to property group menus

Additional Document Info

start page

  • 759

end page

  • 780

volume

  • 14

issue

  • 11

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support