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New treatment options for hearing loss

Academic Article
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Overview

authors

  • Mueller, Ulrich
  • Barr-Gillespie, P. G.

publication date

  • May 2015

journal

  • Nature Reviews Drug Discovery  Journal

abstract

  • Hearing loss is the most common form of sensory impairment in humans and affects more than 40 million people in the United States alone. No drug-based therapy has been approved by the Food and Drug Administration, and treatment mostly relies on devices such as hearing aids and cochlear implants. Over recent years, more than 100 genetic loci have been linked to hearing loss and many of the affected genes have been identified. This understanding of the genetic pathways that regulate auditory function has revealed new targets for pharmacological treatment of the disease. Moreover, approaches that are based on stem cells and gene therapy, which may have the potential to restore or maintain auditory function, are beginning to emerge.

subject areas

  • Animals
  • Cochlear Implantation
  • Drug Design
  • Genetic Therapy
  • Hearing Loss
  • Humans
  • Molecular Targeted Therapy
  • Stem Cell Transplantation
  • United States
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Identity

International Standard Serial Number (ISSN)

  • 1474-1776

Digital Object Identifier (DOI)

  • 10.1038/nrd4533

PubMed ID

  • 25792261
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Additional Document Info

start page

  • 346

end page

  • 365

volume

  • 14

issue

  • 5

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