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Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models

Academic Article
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Overview

authors

  • Svensson, R. U.
  • Parker, S. J.
  • Eichner, L. J.
  • Kolar, M. J.
  • Wallace, M.
  • Brun, S. N.
  • Lombardo, P. S.
  • Van Nostrand, J. L.
  • Hutchins, A.
  • Vera, L.
  • Gerken, L.
  • Greenwood, J.
  • Bhat, S.
  • Harriman, G.
  • Westlin, W. F.
  • Harwood, H. J.
  • Saghatelian, Alan
  • Kapeller, R.
  • Metallo, C. M.
  • Shaw, R. J.

publication date

  • October 2016

journal

  • Nature Medicine  Journal

subject areas

  • Acetyl-CoA Carboxylase
  • Acetyltransferases
  • Allosteric Regulation
  • Animals
  • Carcinoma, Non-Small-Cell Lung
  • Cell Proliferation
  • Enzyme Inhibitors
  • Fatty Acids
  • Humans
  • Lipid Metabolism
  • Lung Neoplasms
  • Mice
  • Mice, Knockout
  • Molecular Targeted Therapy
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins p21(ras)
  • Pyrimidinones
  • Thiophenes
  • Tumor Suppressor Protein p53
  • Xenograft Model Antitumor Assays
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Identity

PubMed Central ID

  • PMC5053891

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm.4181

PubMed ID

  • 27643638
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Additional Document Info

start page

  • 1108

end page

  • 1119

volume

  • 22

issue

  • 10

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