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Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor

Academic Article
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  • Research
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Overview

authors

  • Scheuermann, T. H.
  • Tomchick, D. R.
  • Machius, M.
  • Guo, Y.
  • Bruick, Richard Keith
  • Gardner, K. H.

publication date

  • 2009

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

subject areas

  • Aryl Hydrocarbon Receptor Nuclear Translocator
  • Basic Helix-Loop-Helix Transcription Factors
  • Binding Sites
  • Crystallography, X-Ray
  • Dimerization
  • Humans
  • Ligands
  • Protein Binding
  • Protein Conformation
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Research

keywords

  • NMR
  • X-ray crystallography
  • hypoxia
  • internal cavity
  • protein-ligand interactions
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Identity

PubMed Central ID

  • PMC2626723

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0808092106

PubMed ID

  • 19129502
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Additional Document Info

start page

  • 450

end page

  • 455

volume

  • 106

issue

  • 2

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