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Characterization of kappa opioid receptor mediated, dynorphin-stimulated [(35)S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting

Academic Article
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  • Research
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Overview

authors

  • Zhou, L.
  • Stahl, E. L.
  • Lovell, K. M.
  • Frankowski, K. J.
  • Prisinzano, T. E.
  • Aube, J.
  • Bohn, Laura

publication date

  • December 2015

journal

  • Neuropharmacology  Journal

subject areas

  • Analgesics, Opioid
  • Animals
  • Benzeneacetamides
  • Corpus Striatum
  • Drug Evaluation, Preclinical
  • Dynorphins
  • Guanosine 5'-O-(3-Thiotriphosphate)
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Narcotic Antagonists
  • Protein Binding
  • Pyrrolidines
  • Receptors, Opioid, kappa
  • Signal Transduction
  • Sulfur Radioisotopes
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Research

keywords

  • Drug discovery
  • Dynorphin
  • KOR antagonist
  • Kappa opioid receptor
  • Mouse striatum
  • Selectivity
  • [S-35]GTP gamma S binding
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Identity

PubMed Central ID

  • PMC4655192

International Standard Serial Number (ISSN)

  • 0028-3908

Digital Object Identifier (DOI)

  • 10.1016/j.neuropharm.2015.07.001

PubMed ID

  • 26160155
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Additional Document Info

start page

  • 131

end page

  • 141

volume

  • 99

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