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Discovery and optimization of a series of pyrimidine-based phosphodiesterase 10A (PDE10A) inhibitors through fragment screening, structure-based design, and parallel synthesis

Academic Article
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Overview

authors

  • Shipe, William D
  • Sharik, S. S.
  • Barrow, J. C.
  • McGaughey, G. B.
  • Theberge, C. R.
  • Uslaner, J. M.
  • Yan, Y. W.
  • Renger, J. J.
  • Smith, S. M.
  • Coleman, P. J.
  • Cox, C. D.

publication date

  • October 2015

journal

  • Journal of Medicinal Chemistry  Journal

subject areas

  • Animals
  • Chemistry Techniques, Synthetic
  • Crystallography, X-Ray
  • Disease Models, Animal
  • Dizocilpine Maleate
  • Drug Discovery
  • Drug Evaluation, Preclinical
  • Humans
  • Male
  • Phosphodiesterase Inhibitors
  • Phosphoric Diester Hydrolases
  • Pyrimidines
  • Rats, Wistar
  • Schizophrenia
  • Structure-Activity Relationship
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Identity

International Standard Serial Number (ISSN)

  • 0022-2623

Digital Object Identifier (DOI)

  • 10.1021/acs.jmedchem.5b00983

PubMed ID

  • 26378882
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Additional Document Info

start page

  • 7888

end page

  • 7894

volume

  • 58

issue

  • 19

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