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3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts

Academic Article
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Overview

authors

  • Brnardic, E. J.
  • Fraley, M. E.
  • Garbaccio, Robert
  • Layton, M. E.
  • Sanders, J. M.
  • Culberson, C.
  • Jacobson, M. A.
  • Magliaro, B. C.
  • Hutson, P. H.
  • O'Brien, J. A.
  • Huszar, S. L.
  • Uslaner, J. M.
  • Fillgrove, K. L.
  • Tang, C.
  • Kuo, Y.
  • Sur, S. M.
  • Hartman, G. D.

publication date

  • 2010

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Allosteric Regulation
  • Animals
  • Antipsychotic Agents
  • Ketamine
  • Oxazolidinones
  • Rats
  • Receptors, Metabotropic Glutamate
  • Schizophrenia
  • Structure-Activity Relationship
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Research

keywords

  • Hit to lead
  • Metabotropic glutamate receptors
  • Oxazolidinone
  • Positive allosteric modulator
  • Schizophrenia
  • mGluR2
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2010.03.089

PubMed ID

  • 20409708
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Additional Document Info

start page

  • 3129

end page

  • 3133

volume

  • 20

issue

  • 10

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