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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors

Academic Article
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  • Research
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Overview

authors

  • Fucini, R. V.
  • Hanan, E. J.
  • Romanowski, M. J.
  • Elling, R. A.
  • Lew, W.
  • Barr, K. J.
  • Zhu, J.
  • Yoburn, J. C.
  • Liu, Y.
  • Fahr, B. T.
  • Fan, J.
  • Lu, Y.
  • Pham, P.
  • Choong, I. C.
  • VanderPorten, E. C.
  • Bui, M.
  • Purkey, Hans
  • Evanchik, M. J.
  • Yang, W.

publication date

  • October 2008

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Adenosine Triphosphate
  • Amino Acid Motifs
  • Cell Cycle
  • Cell Cycle Proteins
  • Chemistry, Pharmaceutical
  • Crystallography, X-Ray
  • Drug Design
  • Humans
  • Inhibitory Concentration 50
  • Models, Chemical
  • Molecular Conformation
  • Phenotype
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins
  • Pyrazoles
  • Pyridines
  • Structure-Activity Relationship
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Research

keywords

  • 2-amino-pyrazolopyridine
  • Polo-like kinase (Plk)
  • SAR
  • kinase inhibitor
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2008.08.095

PubMed ID

  • 18793847
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Additional Document Info

start page

  • 5648

end page

  • 5652

volume

  • 18

issue

  • 20

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