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A new FronTIR in targeted protein degradation and plant development

Academic Article
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Overview

authors

  • Nemhauser, J. L.
  • Chory, Joanne

publication date

  • July 2005

journal

  • Cell  Journal

abstract

  • Three papers, two in a recent issue of Nature and one in the July issue of Developmental Cell, identify a family of F box proteins as the long-sought receptors for the plant growth hormone auxin. The new studies reveal that auxin, a small molecule, regulates F box proteins, which are involved in ubiquitin-mediated protein degradation. This finding has profound implications for understanding plant physiology and development and for defining new modes of regulation of SCF ubiquitin ligase complexes.

subject areas

  • Arabidopsis Proteins
  • DNA-Binding Proteins
  • F-Box Proteins
  • Gene Expression Regulation, Plant
  • Indoleacetic Acids
  • Plant Proteins
  • Plants
  • Receptors, Cell Surface
  • Repressor Proteins
  • SKP Cullin F-Box Protein Ligases
  • Transcription Factors
  • Transcriptional Activation
  • Ubiquitin
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2005.06.020

PubMed ID

  • 15989947
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Additional Document Info

start page

  • 970

end page

  • 972

volume

  • 121

issue

  • 7

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