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Molecular evolution of Theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents

Academic Article
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Overview

authors

  • Larsson, A. K.
  • Shokeer, A.
  • Mannervik, Bengt

publication date

  • May 2010

journal

  • Archives of Biochemistry and Biophysics  Journal

subject areas

  • Animals
  • Antineoplastic Agents, Alkylating
  • Carmustine
  • Catalysis
  • Escherichia coli
  • Evolution, Molecular
  • Glutathione Transferase
  • Humans
  • Mice
  • Models, Molecular
  • Mutation
  • Nitrobenzenes
  • Structure-Activity Relationship
  • Substrate Specificity
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Research

keywords

  • 1,3-Bis-(2-chloroethyl)-1-nitrosourea (BCNU) Chloroethylnitrosoureas (CENUs)
  • Alkylating agents
  • Alkyltransferase
  • Directed evolution
  • Glutathione transferase (GST)
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Identity

International Standard Serial Number (ISSN)

  • 0003-9861

Digital Object Identifier (DOI)

  • 10.1016/j.abb.2010.03.001

PubMed ID

  • 20211594
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Additional Document Info

start page

  • 28

end page

  • 34

volume

  • 497

issue

  • 1-2

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