Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Psychiatric blood biomarkers: avoiding jumping to premature negative or positive conclusions

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Niculescu, Alexander
  • Levey, D.
  • Le-Niculescu, H.
  • Niculescu, E.
  • Kurian, S. M.
  • Salomon, Daniel

publication date

  • March 2015

journal

  • Molecular Psychiatry  Journal

abstract

  • Blood biomarkers may provide a scientifically useful and clinically usable peripheral signal in psychiatry, as they have been doing for other fields of medicine. Jumping to premature conclusions, negative or positive, can create confusion in this field. Reproducibility is a hallmark of good science. We discuss some recent examples from this dynamic field, and show some new data in support of previously published biomarkers for suicidality (SAT1, MARCKS and SKA2). Methodological clarity and rigor in terms of biomarker discovery, validation and testing is needed. We propose a set of principles for what constitutes a good biomarker, similar in spirit to the Koch postulates used at the birth of the field of infectious diseases.

subject areas

  • Acetyltransferases
  • Biomarkers
  • Bipolar Disorder
  • Chromosomal Proteins, Non-Histone
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Male
  • Membrane Proteins
  • Middle Aged
  • Suicide
scroll to property group menus

Identity

PubMed Central ID

  • PMC4357859

International Standard Serial Number (ISSN)

  • 1359-4184

Digital Object Identifier (DOI)

  • 10.1038/mp.2014.180

PubMed ID

  • 25582618
scroll to property group menus

Additional Document Info

start page

  • 286

end page

  • 288

volume

  • 20

issue

  • 3

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support