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A weighted polygenic risk score using 14 known susceptibility variants to estimate risk and age onset of psoriasis in han chinese

Academic Article
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Overview

authors

  • Yin, X.
  • Cheng, H.
  • Lin, Y.
  • Wineinger, Nathan
  • Zhou, F.
  • Sheng, Y.
  • Yang, C.
  • Li, P.
  • Li, F.
  • Shen, C.
  • Yang, S.
  • Schork, Nicholas
  • Zhang, X.

publication date

  • 2015

journal

  • PLoS One  Journal

abstract

  • With numbers of common variants identified mainly through genome-wide association studies (GWASs), there is great interest in incorporating the findings into screening individuals at high risk of psoriasis. The purpose of this study is to establish genetic prediction models and evaluate its discriminatory ability in psoriasis in Han Chinese population. We built the genetic prediction models through weighted polygenic risk score (PRS) using 14 susceptibility variants in 8,819 samples. We found the risk of psoriasis among individuals in the top quartile of PRS was significantly larger than those in the lowest quartile of PRS (OR = 28.20, P < 2.0×10(-16)). We also observed statistically significant associations between the PRS, family history and early age onset of psoriasis. We also built a predictive model with all 14 known susceptibility variants and alcohol consumption, which achieved an area under the curve statistic of ~ 0.88. Our study suggests that 14 psoriasis known susceptibility loci have the discriminating potential, as is also associated with family history and age of onset. This is the genetic predictive model in psoriasis with the largest accuracy to date.
  • With numbers of common variants identified mainly through genome-wide association studies (GWASs), there is great interest in incorporating the findings into screening individuals at high risk of psoriasis. The purpose of this study is to establish genetic prediction models and evaluate its discriminatory ability in psoriasis in Han Chinese population. We built the genetic prediction models through weighted polygenic risk score (PRS) using 14 susceptibility variants in 8,819 samples. We found the risk of psoriasis among individuals in the top quartile of PRS was significantly larger than those in the lowest quartile of PRS (OR = 28.20, P < 2.0�10(-16)). We also observed statistically significant associations between the PRS, family history and early age onset of psoriasis. We also built a predictive model with all 14 known susceptibility variants and alcohol consumption, which achieved an area under the curve statistic of ~ 0.88. Our study suggests that 14 psoriasis known susceptibility loci have the discriminating potential, as is also associated with family history and age of onset. This is the genetic predictive model in psoriasis with the largest accuracy to date.

subject areas

  • Adolescent
  • Adult
  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Alcohol Drinking
  • Area Under Curve
  • Case-Control Studies
  • Child
  • Child, Preschool
  • China
  • Female
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Male
  • Middle Aged
  • Models, Genetic
  • Polymorphism, Single Nucleotide
  • Proportional Hazards Models
  • Psoriasis
  • Risk Factors
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Identity

PubMed Central ID

  • PMC4416725

International Standard Serial Number (ISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0125369

PubMed ID

  • 25933357
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Additional Document Info

start page

  • e0125369

volume

  • 10

issue

  • 5

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