Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Albumin-oxanorbornadiene conjugates formed ex vivo for the extended circulation of hydrophilic cargo

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

related to degree

  • Higginson, Cody, Ph.D. in Chemistry, Scripps Research 2010 - 2015

authors

  • Higginson, Cody
  • Eno, M. R.
  • Khan, S.
  • Cameron, Michael
  • Finn, M.G.

publication date

  • August 2016

journal

  • ACS Chemical Biology  Journal

abstract

  • Oxanorbornadiene dicarboxylate (OND) reagents were explored for the purpose of binding and releasing chemical cargos from endogenous circulating serum albumins. ONDs bearing gadolinium chelates as model cargos exhibited variable conjugation efficiencies with albumin in rat subjects that are consistent with the observed reactivity of each linker and their observed stability toward serum hydrolases in vitro. The terminal elimination rate from circulation was dependent on the identity of the OND used, and increased circulation time of gadolinium cargo was achieved for linkers bearing electrophilic fragments designed to react with cysteine-34 of circulating serum albumin. This binding of and release from endogenous albumin highlights the potential of OND linkers in the context of optimizing the pharmacokinetic parameters of drugs or diagnostic agents.
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1554-8929

Digital Object Identifier (DOI)

  • 10.1021/acschembio.6b00444

PubMed ID

  • 27348438
scroll to property group menus

Additional Document Info

start page

  • 2320

end page

  • 2327

volume

  • 11

issue

  • 8

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support