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Synthesis and biopharmaceutical evaluation of imatinib analogues featuring unusual structural motifs

Academic Article
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Overview

related to degree

  • Totokotsopoulos, Sotirios, Ph.D. in Chemistry, Scripps Research 2009 - 2014

authors

  • Nicolaou, K.C.
  • Vourloumis, D.
  • Totokotsopoulos, Sotirios
  • Papakyriakou, A.
  • Karsunky, H.
  • Fernando, H.
  • Gavrilyuk, J.
  • Webb, D.
  • Stepan, A. F.

publication date

  • 2016

journal

  • ChemMedChem  Journal

subject areas

  • Antineoplastic Agents
  • Cell Line, Tumor
  • Cell Proliferation
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Fusion Proteins, bcr-abl
  • Humans
  • Imatinib Mesylate
  • Models, Molecular
  • Molecular Structure
  • Protein Kinase Inhibitors
  • Structure-Activity Relationship
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Research

keywords

  • 1
  • 1]pentanes
  • anticancer agents
  • biopharmaceuticals
  • cubane and bicyclo[1
  • gleevec
  • imatinib analogues
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Identity

International Standard Serial Number (ISSN)

  • 1860-7179

Digital Object Identifier (DOI)

  • 10.1002/cmdc.201500510

PubMed ID

  • 26585829
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Additional Document Info

start page

  • 31

end page

  • 37

volume

  • 11

issue

  • 1

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