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The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

Academic Article
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Overview

authors

  • Datta-Mannan, A.
  • Lu, J.
  • Witcher, D. R.
  • Leung, D.
  • Tang, Ying
  • Wroblewski, V. J.

publication date

  • 2015

journal

  • MAbs  Journal

subject areas

  • Animals
  • Antibodies, Monoclonal, Humanized
  • Antibody Affinity
  • Complementarity Determining Regions
  • Histocompatibility Antigens Class I
  • Humans
  • Immunoglobulin G
  • Macaca fascicularis
  • Metabolic Clearance Rate
  • Mice
  • Protein Binding
  • Protein Engineering
  • Receptors, Fc
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Research

keywords

  • antibody pharmacokinetics
  • charge interactions of IgGs
  • neonatal Fc receptor (FcRn)
  • non-specific binding
  • target mediated disposition
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Identity

PubMed Central ID

  • PMC4966429

International Standard Serial Number (ISSN)

  • 1942-0862

Digital Object Identifier (DOI)

  • 10.1080/19420862.2015.1075109

PubMed ID

  • 26337808
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Additional Document Info

start page

  • 1084

end page

  • 1093

volume

  • 7

issue

  • 6

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