Ligand-enabled stereoselective β-C(sp(3))-H fluorination: Synthesis of unnatural enantiopure anti-β-fluoro-α-amino acids

Academic Article
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publication date

  • 2015

abstract

  • A quinoline-based ligand was shown to promote palladium-catalyzed β-C(sp(3))-H fluorination for the first time. A range of unnatural enantiopure fluorinated α-amino acids were obtained through sequential β-C(sp(3))-H arylation and subsequent stereoselective fluorination from readily available L-alanine.